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Chunk #23 — EPs as a multivariate problem

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Endophenotype: a conceptual analysis.
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and complementary from a research perspective. That is, if paths a11 and aPD1 are high, then EP1 will function as a good risk indicator for the first genetic risk factor. If paths a22 and aPD2 are high, then EP2 will function as a good risk indicator for the second genetic risk factor. Thus, in this situation, each EP indexes a different set of risk genes for PD.