Other genome-wide significant SNPs were in the ARL15 gene on chromosome 5 (rs35951, rs35952) and the UTP20 gene on chromosome 12 (rs57083795). These SNPs also showed suggestive evidence of association (P < 5 × 10−5) with the AD and AD symptom counts in this family based dataset. ARL15 was previously shown to be associated with adiponectin levels, but the exact function of this gene is still unknown (Richards et al., 2009). Several studies have found that adiponectin levels are elevated in patients with chronic alcohol abuse (Buechler et al., 2009) and might also be associated with alcohol craving (Hillemacher et al., 2009). The enrichment analysis using HaploReg showed that SNPs identified at this locus in the COGA dataset predicted significant (p < 5.2 × 10−4) enrichment of enhancers in H1 and leukemia cell lines. There was also evidence (p = 3.1 × 10−2) of enrichment of DNase hypersensitive sites in undifferentiated embryonic stem cells. The UTP20 gene on chromosome 12 is a component of the U3 small nucleolar RNA protein complex and is involved in 18S rRNA processing (Wang et
