LincRNAs are usually associated with open chromatin signatures such as histone modification sites. There is emerging evidence suggesting that lincRNAs regulate gene expression both during normal development and under pathological conditions, including neuropsychiatric disorders (Dudley et al., 2011; Mattick, 2009). We utilized the HaploReg tool (Ward and Kellis, 2012) to explore the annotations of the non-coding genome for the significant SNPs and found no significant enrichment of regulatory markers at this locus. The strongest signals on chromosome 3 were also in moderate LD (D’=1, r2 = 0.42) with SNPs in the neighboring SI gene. The SI gene encodes a sucrase-isomaltase enzyme, which is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltase.
