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Chunk #31 — DISCUSSION

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Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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KGG gene‐based analyses implicated a high‐LD region on chromosome 3 that included many significant genes associated with Cz and occipital alpha power. Variants in this region have been associated with schizophrenia and bipolar disorder. Significant brain‐tissue eQTLs pointed to ITIH4, GNL3, and GLYCTK as genes with altered expression. MetaXcan significantly associated widespread brain expression for ITIH4, with hypothalamic expression reaching significance. For GNL3, hypothalamic and cerebellar tissues significantly associated with alpha oscillations. Hippocampal GLYCTK expression associated with Cz and occipital alpha. MetaXcan further associated cortical TEX264 expression to alpha oscillations. By using expression analyses, we were able to strongly reduce the number of target genes in the chromosome 3 region from twenty‐four to four, and localize their effects to hypothalamic and hippocampal expression as most strongly associated with alpha oscillations.