Chunk #10 — Methods — Statistical Analyses — Calculating Polygenic Risk Scores.

Source

Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users.

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To maximize prediction, we used a variation of PRS-CS, PRS-CSx32 (https://github.com/getian107/PRScsx) in the African ancestries subset of COGA. We used GWAS summary statistics from both the PGC GWAS of European ancestry and a GWAS meta-analysis of schizophrenia in African ancestry individuals33 (Ncases = 7509, Ncontrols = 8337, from the Cooperative Studies Program (CSP) #572 and the Genomic Psychiatry Cohort) to create meta-analyzed combined weights.