We also created a PRS for cannabis use disorder (CUD) in the European ancestry individuals in COGA using a “leave-one-out” version (N = 356 763) of a CUD GWAS11 that excluded the COGA sample. We only performed the leave-one-out analysis in the European ancestry GWAS, and thus only created PRS in the European ancestry subset of COGA, due to the severely limited statistical power of the African ancestry GWAS with the COGA sample excluded from the discovery GWAS (with COGA removed, remaining cases = 3035).
