et al., 2016; Meruelo et al., 2017; Squeglia et al., 2015; Müller-Oehring et al., 2017; Sullivan et al., 2016; Whelan et al., 2014). Alcohol hangover symptoms not only reflect an immediate consequence of excessive consumption that causes distress in the drinker (McKinney, 2010), they also uniquely predict acute cognitive impairment in adults (Ling et al., 2010), relate to worsened neurocognition in adolescents (McQueeny et al., 2009; Squeglia et al., 2009), and prospectively predicts later alcohol use disorder onset in adults (Piasecki et al., 2005). Of particular relevance to ABCD are findings that suggest that the studies examining pathophysiology of hangover in adults reveal that it likely involves a neuroinflammatory process (Penning et al., 2010; Verster, 2008), that may be similar to that observed in alcohol-related brain damage (esp. in frontal and hippocampal regions) in rodent models (Crews and Nixon, 2009). That is, hangover may represent an index of alcohol-related neurotoxicity that is associated with more persistent cognitive deficits.
