When compared with model 1, some of the variables in model 2 lost statistical significance after the addition of family environmental variables, although their odds ratios remained largely unchanged. In the AUD class this was true for the HG-HE risk group and maternal depression. In the SUD-CD class paternal externalizing disorder was no longer significant. However, maternal depression and sibling alcohol use remained significantly associated with membership in the AUD-MDD-ANX class and sibling polydrug use remained significantly associated with each affected class as compared to the non-affected class.
