Adjustment for offspring reports of peer substance use in model 3 (Table 4) showed associations of friends’ current smoking with membership in all affected classes and friends’ weekly drinking with membership in the AUD class. Few changes were observed in the magnitude of association between familial risk factors, family environment variables and class membership from Model 2. For example, the association between HG-HE risk group and membership in the AUD class was similar to that observed in models 1 and 2 (ORs =1.63, 1.50, and 1.60, respectively), and evidence for an association between maternal depression and the AUD class, and for an association of lack of paternal closeness with membership in the SUD-CD class remained. All other variables significant in model 2 retained significance after adjusting for friend substance use, and the pattern of association between family environmental variables and class membership was largely unchanged from that observed in model 2.
