Chunk #26 — RESULTS — Genetic correlations — Are behavioural disinhibition and substance use phenotypes differentially genetically correlated with other phenotypes?
A similar pattern emerged for the behavioural disinhibition and substance use factors in the BD-SUB model such that point estimates were similar and confidence intervals were often overlapping. χ2 difference tests indicated that 21 of 84 criteria were differentially associated with the behavioural disinhibition and substance use factors (see Figure 4C and Table S6). The correlation between the effect sizes for the two factors was 0.95 (0.01), and the median difference in correlations was 0.06 (Figure 4D). The greatest differences were observed for drinks per week (rgBD = 0.36, rgSUB = 0.57, |Δrg| = 0.20), maternal smoking around birth (rgBD = 0.65, rgSUB = 0.83, |Δrg| = 0.18), antisocial behaviour (rgBD = 0.74, rgSUB = 0.59, |Δrg| = 0.15).
