Our results, finding differences between ALC and controls in multiple networks, are in agreement with work showing resting state connectivity altered with other substance use from cocaine (Krmpotich et al., 2013, Gu et al., 2010), heroin (Upadhyay et al., 2010), and prescription opioids (Upadhyay et al., 2010) to alcohol (Camchong et al., 2013, Chanraud et al., 2011). The lower resting state connectivity we report in the SM network also agrees with task-related results finding reduced connectivity between premotor and cerebellar regions in alcoholics and is consistent with neuropatholocial deficits associated with alcoholism (Rogers et al., 2012). However, Chanraud et al (2011) reported that controls (n=15) had more positive resting state connectivity within the default mode network that ALC subjects (n=15) which we did not find. Further Camchong et al. (2012) found than relapsing alcoholics (n=29) had lower connectivity within not only the ECNs, but also within reward, visual and salience networks than abstainers (n=40), networks where we did not find significant effects, possibly attributable to our large sample of subjects with varying degrees of disorder. Our study also did not
