In addition to increases in gene expression, there are 101 genes that decrease expression in the wildtypes following OLM training compared to homecage (Fig7B) and 76 genes that decrease in the Baf53b+/− het mice. Of the 101 genes that decrease in the wildtype, 14 also decrease in the Baf53b+/− het mice (Supplemental Table S9) and 87 do not (Supplemental Table S10). The 87 genes that fail to show an activity-dependent decrease in expression in the Baf53b+/− het mice are enriched for GO terms involving cell homeostasis, postsynaptic cell membrane, and cytoskeleton. In addition to the impaired decrease in gene expression, the Baf53b+/− het mice also have 62 genes that decrease in expression following behavior that do not decrease in the wildtype (Supplemental Table S11). These aberrantly decreased genes are enriched for GO terms involving mitochondria function.
