significantly induced in Baf53b+/− het mice following training (Supplemental Table S5). These genes were enriched for Gene Ontology (GO)35-38 terms for regulation of transcription, RNA processing, and intracellular signaling and included the majority of IEGs (Supplemental Table S6, Fig 7C & D). This suggests that BAF53b and nucleosome remodeling do not affect IEG expression during memory consolidation and that the long-term memory impairments observed in Baf53b+/− het mice are caused by different mechanisms. Of the 300 genes that were increased in the wildtype following OLM training, 176 failed to significantly increase in the Baf53b+/− het mice (Fig 7B, Supplemental Table S7). These genes were enriched for GO terms involving transcription regulation and neurogenesis, as well as chromosome organization and chromatin modification, indicating a potential role for BAF53b in organizing higher order chromatin structure. In the Baf53b+/− het mice there were also a group of genes (171) that were induced following behavior that are not normally increased in the wildtype (Fig 7B, Supplemental Table S8). These genes were enriched for GO terms involving regulation of cell death, glutamate release, behavioral response to drugs of abuse, synaptic transmission, and regulation of neurogenesis.
