We first compared the expression profiles of the wildtype and Baf53b+/− het mice homecage groups and found that the majority of genes (19,524) were equivalently expressed at baseline in the two groups (Fig. 7A). There were also groups of genes that showed increased expression (80) in the wildtype compared to Baf53b+/− het mice and the reverse (57) at homecage (Supplemental Tables S1 & S2). We next examined differences in gene expression following training in the wildtype mice. In agreement with numerous studies demonstrating similar findings34, wildtype mice showed robust changes in gene expression including many immediate early genes (IEGs) following OLM training (compared to homecage) (Fig7B, Supplemental Table S3 & 4) indicating that the training period was sufficient to induce activity-dependent gene expression during memory consolidation. In addition, many of the activity-regulated genes (124) increased in the wildtype were also significantly induced in Baf53b+/− het mice following training (Supplemental Table S5). These genes were enriched for Gene Ontology (GO)35-38 terms for regulation of transcription, RNA processing, and intracellular signaling and included the majority of IEGs (Supplemental Table S6, Fig 7C
