Initially, to assess the extent to which our results corresponded with previous GWA studies of BD, we obtained p-values for genotyped markers in the WTCCC (13) and STEP-BD (16) studies; it was the case, however, that most of the top SNPs that we describe were not genotyped directly within these studies. Therefore, we proceeded by investigating the three regions of interest identified in a recent collaborative GWA study (17) within the EA sample in our study (Figure S3). We evaluated the top SNPs from this study that were directly genotyped in our study, as well as other SNPs in the three regions. We assessed both the direction of associations between the two studies, as well as the strength. For comparison, we include the results from these studies in the plots of regions of interest (Figure S2). Although limited, we further analyzed our results relative to one of the single previously published GWA studies (i.e., Baum et al., 2008) (15), which included about half of the probands and controls used in the present study, in addition to a replication sample that
