The initial 10,000 GPC participants drawn from earlier studies include our Portuguese Island Collection (PIC) of individuals and multiplex families with schizophrenia and/or bipolar disorder. The PIC sampled a homogeneous population founded 500 years ago on two island archipelagos off the coast of Portugal (Pato et al, 2004; Sklar et al, 2004). The PIC has been an integral part of the International Schizophrenia Consortium (ISC). We reported, as part of the ISC, on the presence of copy number variants (CNVs) in our population that significantly increased risk at 22q11.2, 15q13.2, and 1q21.1 (ISC, 2008). We also demonstrated that risk for schizophrenia is significantly affected by common polygenic variation and that those risks may also contribute to the risk for bipolar disorder (ISC, 2009). These findings were rapidly replicated in other studies (Stefansson et al., 2008; Stefansson et al., 2009; Shi et al., 2009). Our group has continued to extend these findings in a number of follow-up publications (Ng et al., 2009; O’Dushlaine et al., 2011; Gilks et al, 2010; Moskvina et al., 2010; Chen et al., 2011; Raychaudhuri et al.,
