The Center for Genomic Psychiatry at the University of Southern California (USC) and an extensive network of academic medical centers have created the Genomic Psychiatry Cohort (GPC) (n=33,000). We have ascertained and enrolled a large clinical cohort of patients with schizophrenia (n=10,000), patients with bipolar disorder (n=5,000), family members (n=3,000), and control participants with no personal or family history of schizophrenia or bipolar disorder (n=15,000). The GPC was formed from an initial population of ~10,000 participants from our earlier studies. Over the past four years, we have enrolled an additional 23,000 participants (~9,000 Caucasian, ~5,000 African American, ~8,000 Latino, ~1,000 other).