FGF21. In fact, leptin is a potential regulator of FGF21 (ref.43) and FGF21 can promote metabolic homeostasis via leptin (ref.44). In addition, another adipokine CTRP3 also protected against hepatic steatosis (ref.45). It is possible that PPARα regulates interaction between liver and adipose tissue through the liver released FGF21 and adipose tissue released adipokines. Whether CYP2A protects against obesity and fatty liver via interacting with a PPARα-FGF21-adipokine axis needs further studies.
