Power analysis methods are described on page S-19 and results shown in Tables S3 and S4 and Figure S13. Power was computed for a genome-wide significance threshold of P < 5 × 10−8 and additive inheritance. For the primary STAR*D analysis, there was 80% power to detect an allele with a genotypic relative risk (GRR) of 1.70, 1.50, and 1.43 for allele frequencies of 0.1, 0.2, and 0.3; and for the primary meta-analysis, power was approximately 50% for an allele with GRRs of 1.19 or 1.16 for allele frequencies of 20% or 50%, and was approximately 80% with GRR of 1.20 and frequency of 30%.
