On the whole, estimates for two-way interactions between SLE (either personal or network) and the genotypes (either 5HTTLPR or 5HTTLPR + rs25531) on risk of ClinDep, suicidality or SelfRepDep are not significant, irrespective of the mode of action (additive or dominant). There are four exceptions with nominal P< 0.05 (Table III and the Supplementary Information Figure II supp.), and each is in a direction opposite to that expected from Caspi et al. [2003]: with 48 interactions terms in all, these are likely to occur by chance alone.
