We downloaded all KEGG pathways and then compared the list of genes in each pathway and genes with polymorphic target sites in the PolymiRTS database. We use the KEGG API interface to display the biological pathways. Figure 1 shows the ‘Type I diabetes’ pathway. Genes with polymorphisms in miRNA target sites were highlighted with ‘red’ font and ‘red’ box borders. There are two options for browsing biological pathways. The option ‘Experimental’ shows pathways with genes that have polymorphisms in experimentally supported miRNA target sites, including those identified by CLASH experiments. The option ‘ALL’ lists the pathways with genes that have polymorphisms in both predicted and experimentally supported miRNA target sites.
