The PolymiRTS database attempts to link polymorphisms in miRNAs and their target sites with variations in phenotypes and human diseases. These links may span multiple biological scales—from DNA sequence (QTLs) to gene expression and higher-order phenotypes (e.g. diseases). As described in the previous update (20), the PolymiRTS database includes GWAS data from NHGRI GWAS Catalog (40) and dbGaP (41), human expression QTL (eQTL) data from GTEx eQTL browser (42) and mouse QTL data from GeneNetwork (43). Since the last update, there has been a rapid growth of GWAS data. About 8000 newly available GWAS results were processed for the update and 1311 new records were added to the database.