Thirty autosomal loci achieved genome-wide significance (P< 5×10−8) in fixed-effect meta-analysis of our GWAS and follow-up samples (Figure 1, Table 1A, Supplementary Data 1–3, Supplementary Table 4). In Supplementary Table 5, we present detailed descriptions of the associated loci and genes, with bioinformatic and literature evidence for their potential roles in BD. Of the 30 genome-wide significant loci from our combined analysis, 20 are novel BD risk loci. These include 19 loci that were significant only in the combined analysis, of which three were reported to have genome-wide significant SNPs in previous studies (ADCY2 18, POU3F2 18, ANK3 12,18), and 11 that were significant in our primary GWAS. We refer to loci by the gene name attributed in previous BD GWAS publications, or by the name of the closest gene for novel loci, without implication that the named gene is causal. Results for all variants tested in the follow-up study are presented in Supplementary Table 4.
