In contrast, AO-AD GRS from COGA explained only a very modest (but significant) proportion of variation in AO-AD (0.06–0.07%) and AD (0.03–-0.06%) in OZ-ALC (Table 2 and Figure 2). The GRS were modestly associated with AO-I (0.2–0.3%), as well as with AD-SX (0.09–0.13%) and Maxdrinks (0.004–0.05%) in OZ-ALC. The associations were far less significant than those noted in SAGE, explaining ⩽0.16% of the variance in alcohol-related phenotypes. Height was included as a negative control and was not associated (P>0.05) with any GRS across SAGE and OZ-ALC.
