As shown in Table 2 and Figure 1, GRS for AO-AD were significantly associated with AO-AD and also with AD in SAGE for cutoffs above GRS0.05. Increasing P-value thresholds resulted in greater proportion of variance explained with the adjusted R2 ranging from 0.3% for GRS0.1 to 0.7% for GRS0.5. The variance explained was maximum when we included the SNPs with P⩽0.5. In addition to AO-AD, GRS explained a modest proportion of the variance in AO-I (≈0.3%). GRS from COGA were also related to AD-SX and Maxdrinks in SAGE, explaining 0.2 to 0.8% of the variance in these measures.
