examine the impact of this post hoc adjustment on the tail discrimination of the PRS, we compared the OR of individuals in the top percentiles of the adjusted PRS across ancestries with the OR of individuals in the top percentiles of the raw PRS within each ancestry (i.e., OR estimates reported in Table 2 and Additional File 2: Table S3). Additional File 2: Table S7 shows that other than the OR estimate at top 2% of the PRS in the Hispanic/Latino samples, which was affected by a relatively low sample size and large estimation uncertainties, high-risk individuals identified by the adjusted PRS using a single cutoff showed comparable or slightly higher OR estimates than those identified by the raw PRS separately in each ancestral group, suggesting that the ancestry adjustment method did not compromise the predictive performance of the trans-ancestry PRS.
