We have shown that the top 2% of a trans-ancestry PRS distribution can identify individuals of European, African, Hispanic/Latino, and East Asian ancestry with a roughly 2.5–4.5-fold of increase in T2D risk, which corresponds to numerous studies that showed a similar increased risk of T2D for first degree relatives (see e.g., [41]). By integrating GWAS summary statistics from multiple populations using PRS-CSx, the trans-ancestry PRS was significantly associated with T2D status in all populations examined, providing a robust and potentially clinically meaningful index of risk among diverse patients in clinical settings.
