Chunk #19 — RESULTS — PPARα absence in cyp2a5−/− mice blunts HFD-induced obesity but enhances HFD-induced fatty liver

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CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.

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panel) and P-A+ mice (Fig. 3C right panel); HFD feeding worsen the glucose intolerance in P+A- mice but HFD had no effect on glucose intolerance in P-A- mice and P-A+ mice (Fig. 3C). Pyruvate tolerance test showed that blood glucose in response to pyruvate injection was lower in P-A- mice than in P+A- mice (Fig. 3D), suggesting a lower capacity for liver gluconeogenesis in P-A- mice than in P+A- mice.