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Chunk #21 — Results — The relative molecular mass (Mr) of MOPR in G/G mice was lower than that in A/A mice, which is due to differences in N-glycosylation of MOPR

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A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.
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(Fig. 2, right panel, lane 1 vs lane 3). Similarly, the striatal MOPR band in G/G mice had a lower Mr range, 53-76 kDa (median, 66 kDa) (Fig. 2, right panel, lane 2 vs lane 3). The same experiments were performed on brain tissues of male mice and similar results were obtained (data not shown). There were no sex differences in the Mr of the MOPR.