paperKB
coga / coga-kb
Help
Sign in

Chunk #18 — Results — Main Analysis

Source
A GABRA2 polymorphism improves a model for prediction of drinking initiation.
Embedded
yes

Text

Closer examination of Model 5 (the last column in Table 3) indicated that the four binary predictor variables have adjusted hazard ratios (aHRs) that are higher than those for the two quantitative predictors. This is due to the fact that the two non-binary predictors (the number of CD symptoms and the YSR externalizing score) each had a wider observed range. The aHR was increased 17% for each additional CD symptom (observed range of 0–10) and 3% for each unit increase of the YSR externalizing score (observed range of 0–50). Standardized aHRs (saHR) provide a better way to judge the relative impact of these predictors: (from the most influential predictor to the least) MBFD (saHR = 1.40), externalizing score (saHR = 1.32), EA ancestry (saHR = 1.25), homozygous TT genotype of rs279871 (saHR = 1.23), number of CD symptoms (saHR = 1.22), and high-risk family membership (saHR = 1.17).