Results from analyses with alc-PRS calculated based on GWAS summary statistics with the MVP EA sample were generally consistent with results presented above for the EA subsample, except that the interaction effect between alc-PRS and friend support was not significant. The main effect of alc-PRS on alcohol use was significant, although the effect size was relatively smaller in the sensitivity analysis, which may have hindered the detection of G´ E effects. Detailed results from this set of sensitivity analyses are presented in Supplemental Tables 6–8. Results from the sensitivity analyses with smaller age bands are presented in Supplemental Tables 9 and 10. Results are largely consistent with those conducted with larger age bands, except that the alc-PRS by friend support interaction significantly differed across developmental periods among EAs in the sensitivity analysis. The interaction is significant during ages 30–37 and the effect differed from those in other developmental periods. In addition, the main effect of friend support on alcohol use did not significantly differ across developmental periods among AAs in the sensitivity analysis, which could be due to smaller sample sizes with the smaller age bands and reduced statistical power.
