Last but not least, the functionality of the investigated polymorphism, which has been proven not only in terms of protein levels but also HPA axis response, aims to overcome the fact that Fkbp5 gene expression in vivo cannot be assessed in the human brain. On the other hand, rodents do not carry an orthologous polymorphism. This is therefore an imperfect translational study whose results can be difficult to interconnect and should be seen as a valuable complement to each other.
