Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans.

paper Cited Public

Authors: Nylander, Ingrid; Todkar, Aniruddha; Granholm, Linnea; Vrettou, Maria; Bendre, Megha; Boon, Wout; Andershed, Henrik; Tuvblad, Catherine; Nilsson, Kent W; Comasco, Erika
Year: 2017
Journal: Molecular neurobiology
PMID: 27709495
DOI: 10.1007/s12035-016-0157-z
PMCID: PMC5583263

#	Section	Preview
0	Introduction	The FK506-binding protein 5 (FKBP5) has been recently proposed as a drug target for treatment of…
1	Introduction	Early life stress (ELS), in interaction with the genetic make-up, can alter programming of the brain…
2	Introduction	Corticosterone, the principal glucocorticoid in rodents, through GRs, increases dopaminergic…
3	Introduction	Alcohol affects the mesocorticolimbic and striatal circuitries as well as the HPA axis response [21,…
4	Introduction	The Fkbp5/FKBP5 genotype in rodents and humans, respectively, has been associated with differences…
5	Introduction	Poor social interactions during early life, such as poor parent-offspring relationship, constitute a…
6	Methods and Materials — Study of Rodents	The study was approved by the Uppsala Animal Ethical Committee (C32/11), according to the Swedish…
7	Methods and Materials — Study of Rodents — Early Life Rearing Conditions	During the first three postnatal weeks, ELS was simulated by repeated prolonged maternal separations…
8	Methods and Materials — Study of Rodents — Voluntary Alcohol Consumption	On postnatal week 10, the MS rats were single housed and randomly assigned to water drinking (MS15W,…
9	Methods and Materials — Study of Rodents — Genetic Analyses	RNA was isolated and converted to cDNA. Diluted cDNA (20×) was used to assess the expression of…
10	Methods and Materials — Study of Rodents — Corticosterone Measurement	Samples were analyzed as described in [30].
11	Methods and Materials — Study of Humans	The Regional Ethical Review Board approved the study (2010/463). Individuals were participants of…
12	Methods and Materials — Study of Humans — The Alcohol Use Disorders Identification Test	All participants completed the 10-item Alcohol Use Disorders Identification Test (AUDIT)…
13	Methods and Materials — Study of Humans — Parent-Child Relationship	Parent-child relationship was measured using the following items: “When you were growing up…
14	Methods and Materials — Study of Humans — Genotyping	DNA was extracted from 200 μl of saliva collected with the Oragene self-collection kit (DNA…
15	Methods and Materials — Statistical Analyses	Between-group differences were tested using the Mann Whitney U test. The General Linear Model (GLM)…
16	Results — Study of Fkbp5 Expression in Rodents	In the VTA, water-drinking MS15 rats displayed higher Fkbp5 expression compared to MS360 rats (U =…
17	Results — Study of Fkbp5 Expression in Rodents	Interaction effects between ELS and ethanol drinking were observed in the VTA (F = 4.35, p = .043,…
18	Results — Study of Fkbp5 Expression in Rodents	As reported in [30, 35], an interaction effect of ELS and ethanol drinking was found on…
19	Results — Study of Fkbp5 Expression in Rodents	Alcohol intake data have been previously reported [30, 36, 37]. The MS15 and MS360 groups did not…

Name	Type
Acb	cohort
acute reinforcing actions local	phenotype
acute stress	phenotype
addiction	phenotype
adoptive parents	cohort
alcohol	phenotype
alcohol-drinking control rats local	cohort
Alcohol-drinking control rats local	cohort
alcohol-drinking MS15 rats local	cohort
alcohol-drinking MS360 rats local	cohort
alcohol-drinking rats exposed to ELS local	cohort
Alcohol-drinking rats exposed to ELS local	cohort
Alcohol‑drinking rats with ELS local	cohort
alcohol-related problems	phenotype
Alcohol Use	phenotype
Alcohol Use Disorder	phenotype
alcohol withdrawal	phenotype
Amy	anatomy
amygdala	anatomy
Amygdala overreactivity to emotional stimuli local	phenotype
anterior cingulate cortex	anatomy
Attachment	phenotype
attachment construct local	phenotype
AUD	phenotype
AUDIT	phenotype
auditory cues local	phenotype
AUDIT questionnaire local	phenotype
Autonomic response to stress local	phenotype
basolateral amygdala	anatomy
behavior	phenotype
behavior guidance local	phenotype
biological father local	phenotype
biological mother local	phenotype
Biological parents	cohort
bonding typology local	phenotype
brain function	phenotype
caregiver local	phenotype
caudate nucleus	anatomy
central amygdala	anatomy
chronic social defeat stress local	phenotype
cingulate cortex	anatomy
cingulum	anatomy
Cognitive control functioning local	phenotype
compulsive alcohol intake	phenotype
conditioned reinforcing processes local	phenotype
control rats	cohort
cortex	anatomy
corticosterone	drug
corticosterone levels local	phenotype
cortisol response	phenotype
dexamethasone	drug
dopamine	drug
dopaminergic projecting and receiving areas local	anatomy
dorsal striatum	anatomy
drinking	phenotype
Drinking for coping reasons local	phenotype
drugs targeting FKBP5 local	drug
early alcohol use	phenotype
Early life factors local	phenotype
early life interactions local	phenotype
Emotion	phenotype
emotional states local	phenotype
emotion regulation	phenotype
episodic voluntary drinking local	phenotype
ethanol consumption	phenotype
excessive alcohol consumption	phenotype
fear response local	phenotype
fear responses local	phenotype
Fkbp5	gene
FKBP5 genotype local	variant
FKBP5 knock-out local	variant
FKBP5 polymorphism local	variant
FKBP5 rs1360780 T allele local	variant
FKBP5 T allele local	variant
FKBP5 TT genotype	variant
frequency of alcohol use	phenotype
gene expression	phenotype
glucocorticoids	drug
goal-directed behavior	phenotype
hippocampus	anatomy
homosexual parents local	cohort
HPA axis	anatomy
HPA axis response	anatomy
HSP90 local	gene
human alcoholics	phenotype
human brain	anatomy
human population-based sample local	cohort
humans	cohort
incentive salience	phenotype
independence local	phenotype
inferior frontal gyrus	anatomy
insecure bonding local	phenotype
institutional care	phenotype
intermittent voluntary alcohol drinking local	phenotype
Kbioscience Allele-Specific Polymorphism assay local	drug
Kleargene DNA extraction method local	drug
maternal separation	phenotype
medial prefrontal cortex	anatomy
Mesocorticolimbic area local	anatomy
Mesocorticolimbic areas local	anatomy
Mesocorticolimbic system	anatomy
middle frontal gyrus	anatomy
mPFC	anatomy
MS15 local	cohort
MS15 local	phenotype
MS15E local	cohort
MS15 rats local	cohort
MS15W local	cohort
MS360 local	cohort
MS360 local	phenotype
MS360E local	cohort
MS360 rats local	cohort
MS360W local	cohort
MS rats local	cohort
mutuality local	phenotype
negative reinforcement	phenotype
novelty seeking	phenotype
Nr3c1	gene
nucleus accumbens	anatomy
offspring	cohort
Oragene self-collection kit local	drug
orphans local	cohort
outbred rats	cohort
Outbred Wistar male rats local	cohort
parahippocampal gyrus	anatomy
parental deprivation local	phenotype
parental regard local	phenotype
parent-child relationship	phenotype
parenting style local	phenotype
parents’ responsiveness local	phenotype
patchwork families local	cohort
physical abuse	phenotype
poor parent-child relationship local	phenotype
Poor parent-offspring relationship local	phenotype
population-based sample	cohort
Population-based young male adults local	cohort
posterior cingulate cortex	anatomy
problematic alcohol drinking local	phenotype
problematic use	phenotype
Propensity to increase alcohol intake local	phenotype
protein levels local	phenotype
psychiatric phenotypes with impaired stress response local	phenotype
putamen	anatomy
rats	cohort
reciprocity local	phenotype
reinforcing effects of alcohol local	phenotype
RESUME local	cohort
Reward dependent personality local	phenotype
reward system	anatomy
Reward system (dopaminergic key regions) local	anatomy
risk taking	phenotype
rodents	cohort
rs1360780	variant
rs9296158 local	variant
rs9296158 minor allele local	variant
sex	phenotype
shorter recovery time local	phenotype
shorter recovery time after chronic social defeat stress local	phenotype
single-parent family local	cohort
stressful life events	phenotype
stress induced fear response local	phenotype
Stress‑induced seeking local	phenotype
stress-related disorders	phenotype
stress response	phenotype
Striatal area local	anatomy
striatal circuit local	anatomy
Striatal circuitries local	anatomy
striatum	anatomy
surrogacy local	cohort
tactile cues local	phenotype
ventral tegmental area	anatomy
visual cues local	phenotype
VTA	anatomy
water	drug
water drinking local	phenotype
water-drinking MS15 rats local	cohort
water-drinking MS360 rats local	cohort
Water-drinking rats exposed to ELS local	cohort
withdrawal	phenotype
withdrawal-like symptoms local	phenotype
working memory	phenotype
Young adult cohort	cohort
young adults	cohort
young male adults local	cohort

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In this knowledge base

Title	Year	PMID
Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism.	2019	30765688

External

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