Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.
paper
Cited
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- Authors
- Lee, Richard S; Tamashiro, Kellie L K; Yang, Xiaoju; Purcell, Ryan H; Harvey, Amelia; Willour, Virginia L; Huo, Yuqing; Rongione, Michael; Wand, Gary S; Potash, James B
- Year
- 2010
- Journal
- Endocrinology
- PMID
- 20668026
- DOI
- 10.1210/en.2010-0225
- PMCID
- PMC2940504
There is evidence for hypercortisolemia playing a role in the generation of psychiatric symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis genes mediating behavioral changes. We tested the hypothesis that expression changes would be induced in Fkbp5 and other HPA axis genes by chronic exposure to corticosterone and that these changes would occur through the epigenetic mechanism of loss or gain of DNA methylation (DNAm). We administered corticosterone (CORT) to C57BL/6J mice via their drinking water for 4 wk and tested for behavioral and physiological changes and changes in gene expression levels using RNA extracted from hippocampus, hypothalamus, and blood for the following HPA genes: Fkbp5, Nr3c1, Hsp90, Crh, and Crhr1. The CORT mice exhibited anxiety-like behavior in the elevated plus maze test. Chronic exposure to CORT also caused a significant decrease in the hippocampal and blood mRNA levels of Nr3c1 and a decrease in Hsp90 in blood and caused an increase in Fkbp5 for all tissues. Differences were seen in Fkbp5 methylation in hippocampus and hypothalamus. To isolate a single-cell type, we followed up with an HT-22 mouse hippocampal neuronal cell line exposed to CORT. After 7 d, we observed a 2.4-fold increase in Fkbp5 expression and a decrease in DNAm. In the CORT-treated mice, we also observed changes in blood DNAm in Fkbp5. Our results suggest DNAm plays a role in mediating effects of glucocorticoid exposure on Fkbp5 function, with potential consequences for behavior.
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|---|---|---|---|---|
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| Epigenetics in persons living with HIV: trauma, coping, and <i>FKBP5</i> and <i>SLC6A4</i> methylation. | Tomlinson CJ et al. | β | 2025 | β |
| From intracellular sensors to systemic resilience: Reframing the biology of stress. | Hartmann J | β | 2025 | β |
| How epigenetic inheritance fails to explain the Black-White health gap. | Charney E et al. | β | 2025 | β |
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| Targeted DNA Methylation Using Modified DNA Probes: A Potential Therapeutic Tool for Depression and Stress-Related Disorders. | Modi N et al. | β | 2025 | β |
| The rs1360780 Variant of <i>FKBP5</i>: Genetic Variation, Epigenetic Regulation, and Behavioral Phenotypes. | Arancibia M et al. | β | 2025 | β |
| Adverse effects of early-life stress: focus on the rodent neuroendocrine system. | Lee SH et al. | β | 2024 | β |
| A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. | Arcego DM et al. | β | 2024 | β |
| Changes in DNA methylation associated with a specific mode of delivery: a pilot study. | Krumpolec P et al. | β | 2024 | β |
| Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice. | Shoji H et al. | β | 2024 | β |
| Exploring transcriptional and post-transcriptional epigenetic regulation of crf and 11Ξ²hsd2 in rainbow trout brain during chronic social stress. | Best C et al. | β | 2024 | β |
| Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload. | Eachus H et al. | β | 2024 | β |
| Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders. | GroΓmann NL et al. | β | 2024 | β |
| Promoting sleep health during pregnancy for enhancing women's health: a longitudinal randomized controlled trial combining biological, physiological and psychological measures, Maternal Outcome after THERapy for Sleep (MOTHERS). | Meneo D et al. | β | 2024 | β |
| Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD. | Lee A et al. | β | 2024 | β |
| The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus. | Agam G et al. | β | 2024 | β |
| Extensive evaluation of DNA methylation of functional elements in the murine Fkbp5 locus using high-accuracy DNA methylation measurement via targeted bisulfite sequencing. | Yusupov N et al. | β | 2023 | β |
| Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study. | Sforzini L et al. | β | 2023 | β |
| <i>In vitro</i> modeling of the neurobiological effects of glucocorticoids: A review. | Bassil K et al. | β | 2023 | β |
| Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar-Kyoto Rats. | Valdez MC et al. | β | 2023 | β |
| Investigating the Effects of Maternal Separation on Hypothalamic-Pituitary-Adrenal Axis and Glucose Homeostasis under Chronic Social Defeat Stress in Young Adult Male Rat Offspring. | Eskandari F et al. | β | 2023 | β |
| Molecular biological, physiological, cytological, and epigenetic mechanisms of environmental sex differentiation in teleosts: A systematic review. | Yu Y et al. | β | 2023 | β |
| Oxytocin prevents dysregulation of the acute stress response and glucocorticoid-induced oxidative stress in chronically isolated prairie voles. | Stevenson JR et al. | β | 2023 | β |
| Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery. | Malekpour M et al. | β | 2023 | β |
| Tet Enzyme-Mediated Response in Environmental Stress and Stress-Related Psychiatric Diseases. | Xia M et al. | β | 2023 | β |
| The translational genetics of ADHD and related phenotypes in model organisms. | Cabana-DomΓnguez J et al. | β | 2023 | β |
| Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury. | Boe DM et al. | β | 2022 | β |
| Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene. | Caradonna SG et al. | β | 2022 | β |
| Cortisol and cardiometabolic disease: a target for advancing health equity. | Ortiz R et al. | β | 2022 | β |
| DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention? | Paoli C et al. | β | 2022 | β |
| Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment. | Shenk CE et al. | β | 2022 | β |
| Glucocorticoid Exposure of Preimplantation Embryos Increases Offspring Anxiety-Like Behavior by Upregulating miR-211-5p <i>via</i> Trpm1 Demethylation. | Yuan HJ et al. | β | 2022 | β |
| Glucocorticoid receptor expression as an integrative measure to assess glucocorticoid plasticity and efficiency in evolutionary endocrinology: A perspective. | Jimeno B et al. | β | 2022 | β |
| Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. | Kwon DY et al. | β | 2022 | β |
| Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance. | Mbiydzenyuy NE et al. | β | 2022 | β |
| Characterization of glucocorticoid-induced loss of DNA methylation of the stress-response gene <i>Fkbp5</i> in neuronal cells. | Cox OH et al. | β | 2021 | β |
| Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression. | Lin YL et al. | β | 2021 | β |
| Cross-species Association Between Telomere Length and Glucocorticoid Exposure. | Lee RS et al. | β | 2021 | β |
| Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids. | Larison B et al. | β | 2021 | β |
| Epigenetic models predict age and aging in plains zebras and other equids | Larison B et al. | β | 2021 | β |
| Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model. | Caulfield JI et al. | β | 2021 | β |
| Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. | Hartmann J et al. | β | 2021 | β |
| Perinatal stress and epigenetics. | Szyf M | β | 2021 | β |
| The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms. | Falcinelli M et al. | β | 2021 | β |
| The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations. | Dick A et al. | β | 2021 | β |
| Expression of corticosteroid hormone receptors, prereceptors, and molecular chaperones in hypothalamic-pituitary-adrenal axis and adipose tissue after the administration of growth promoters in veal calves. | Starvaggi Cucuzza L et al. | β | 2020 | β |
| FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention. | Annett S et al. | β | 2020 | β |
| FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism. | Criado-Marrero M et al. | β | 2020 | β |
| FKBP5 gene expression in skeletal muscle as a potential biomarker for illegal glucocorticoid treatment in veal calves. | Starvaggi Cucuzza L et al. | β | 2020 | β |
| Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. | ProvenΓ§al N et al. | β | 2020 | β |
| Health-Related Quality of Life Improvements in Systemic Lupus Erythematosus Derived from a Digital Therapeutic Plus Tele-Health Coaching Intervention: Randomized Controlled Pilot Trial. | Khan F et al. | β | 2020 | β |
| Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis. | Frasch MG et al. | β | 2020 | β |
| Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress. | Palumbo MC et al. | β | 2020 | β |
| Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice. | Savarese AM et al. | β | 2020 | β |
| The stressed brain: regional and stress-related corticosterone and stress-regulated gene expression in the adult zebra finch (Taeniopygia guttata). | Rensel MA et al. | β | 2020 | β |
| A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions. | Blacker CJ et al. | β | 2019 | β |
| Baseline and stress-induced corticosterone levels are heritable and genetically correlated in a barn owl population. | BΓ©ziers P et al. | β | 2019 | β |
| Does epigenetic 'memory' of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator <i>FKBP5</i>. | GΓ©ranton SM | β | 2019 | β |
| Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-ΞΊB-driven inflammation and cardiovascular risk. | Zannas AS et al. | β | 2019 | β |
| Genome-Wide Analysis of Glucocorticoid-Responsive Transcripts in the Hypothalamic Paraventricular Region of Male Rats. | Itoi K et al. | β | 2019 | β |
| Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples. | Braun PR et al. | β | 2019 | β |
| Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration. | Do TTH et al. | β | 2019 | β |
| Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice. | Li B et al. | β | 2019 | β |
| Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models. | Weissenrieder JS et al. | β | 2019 | β |
| Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression. | Klinger-KΓΆnig J et al. | β | 2019 | β |
| Towards precision medicine in generalized anxiety disorder: Review of genetics and pharmaco(epi)genetics. | Tomasi J et al. | β | 2019 | β |
| A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure. | Carey JL et al. | β | 2018 | β |
| Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis. | Dick A et al. | β | 2018 | β |
| Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man. | Santi A et al. | β | 2018 | β |
| DNA methylation and sex-specific expression of FKBP5 as correlates of one-month bedtime cortisol levels in healthy individuals. | Lee RS et al. | β | 2018 | β |
| Early Life Stress as a Predictor of Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder. | Lee RS et al. | β | 2018 | β |
| Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA. | Duis J et al. | β | 2018 | β |
| Effects of troxerutin on anxiety- and depressive-like behaviors induced by chronic mild stress in adult male rats. | Azarfarin M et al. | β | 2018 | β |
| Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression. | Tozzi L et al. | β | 2018 | β |
| Epigenetic Programming Effects of Early Life Stress: A Dual-Activation Hypothesis. | Lux V | β | 2018 | β |
| FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study. | Bustamante AC et al. | β | 2018 | β |
| Glucocorticoids, genes and brain function. | Juszczak GR et al. | β | 2018 | β |
| How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation. | Liu PZ et al. | β | 2018 | β |
| In Vitro Neuroprotection of Rat Hippocampal Neurons by Manninotriose and Astragaloside IV Against Corticosterone-Induced Toxicity. | Zheng J et al. | β | 2018 | β |
| Methylation of <i>FKBP5</i> and <i>SLC6A4</i> in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder. | Bishop JR et al. | β | 2018 | β |
| Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress. | VodiΔka M et al. | β | 2018 | β |
| NPTX2 is a key component in the regulation of anxiety. | Chang S et al. | β | 2018 | β |
| Role of FKBP51 in the modulation of the expression of the corticosteroid receptors in bovine thymus following glucocorticoid administration. | Starvaggi Cucuzza L et al. | β | 2018 | β |
| The clandestine organs of the endocrine system. | Garcia-Reyero N | β | 2018 | β |
| The role of the circadian clock system in physiology. | Pilorz V et al. | β | 2018 | β |
| Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of <i>FKBP5</i>. | Ortiz R et al. | β | 2018 | β |
| Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model. | Matosin N et al. | β | 2018 | β |
| Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. | Holmes SE et al. | β | 2017 | β |
| Elevated paternal glucocorticoid exposure modifies memory retention in female offspring. | Yeshurun S et al. | β | 2017 | β |
| Epigenetic programming by stress and glucocorticoids along the human lifespan. | Zannas AS et al. | β | 2017 | β |
| Epigenetic programming of the neuroendocrine stress response by adult life stress. | Dirven BCJ et al. | β | 2017 | β |
| Epigenomics and human adaptation to high altitude. | Julian CG | β | 2017 | β |
| Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans. | Nylander I et al. | β | 2017 | β |
| Examining FKBP5 mRNA expression in human iPSC-derived neural cells. | Lieberman R et al. | β | 2017 | β |
| Gene expression associated with PTSD in World Trade Center responders: An RNA sequencing study. | Kuan PF et al. | β | 2017 | β |
| Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure. | Seifuddin F et al. | β | 2017 | β |
| Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases. | Gassen NC et al. | β | 2017 | β |
| Maternal programming of sex-specific responses to predator odor stress in adult rats. | St-Cyr S et al. | β | 2017 | β |
| Mechanisms of Brain Glucocorticoid Resistance in Stress-Induced Psychopathologies. | Merkulov VM et al. | β | 2017 | β |
| Reduced DNA methylation and psychopathology following endogenous hypercortisolism - a genome-wide study. | Glad CA et al. | β | 2017 | β |
| The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease. | Fries GR et al. | β | 2017 | β |
| Xenobiotics and the Glucocorticoid Receptor. | Gulliver LS | β | 2017 | β |
| A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons. | Niwa M et al. | β | 2016 | β |
| Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats. | Boersma GJ et al. | β | 2016 | β |
| Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala. | Sawamura T et al. | β | 2016 | β |
| Don't worry; be informed about the epigenetics of anxiety. | Nieto SJ et al. | β | 2016 | β |
| Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants. | Piyasena C et al. | β | 2016 | β |
| Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project. | Lovallo WR et al. | β | 2016 | β |
| Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice. | Cordner ZA et al. | β | 2016 | β |
| FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change. | Rein T | β | 2016 | β |
| Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. | Zannas AS et al. | β | 2016 | β |
| Reduced DNA methylation of FKBP5 in Cushing's syndrome. | Resmini E et al. | β | 2016 | β |
| Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. | Donner NC et al. | β | 2016 | β |
| Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis. | Wiley JW et al. | β | 2016 | β |
| The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. | Qiu B et al. | β | 2016 | β |
| The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. | MaiarΓΉ M et al. | β | 2016 | β |
| Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health. | Nugent NR et al. | β | 2016 | β |
| Accumulation of cytoplasmic glucocorticoid receptor is related to elevation of FKBP5 in lymphocytes of depressed patients. | Lukic I et al. | β | 2015 | β |
| Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: relevance to depression. | Skupio U et al. | β | 2015 | β |
| Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. | Gassen NC et al. | β | 2015 | β |
| Developmental and environmental influences on physiology and behavior--2014 Alan N. Epstein Research Award. | Tamashiro KL | β | 2015 | β |
| Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response. | Kitraki E et al. | β | 2015 | β |
| Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. | Dias BG et al. | β | 2015 | β |
| Epigenetics and memory: causes, consequences and treatments for post-traumatic stress disorder and addiction. | Pizzimenti CL et al. | β | 2015 | β |
| FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis. | Araki T et al. | β | 2015 | β |
| Gene-environment interaction in major depression: focus on experience-dependent biological systems. | Lopizzo N et al. | β | 2015 | β |
| Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans. | Shimada-Sugimoto M et al. | β | 2015 | β |
| Individual differences in the effects of prenatal stress exposure in rodents. | Boersma GJ et al. | β | 2015 | β |
| Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. | Zannas AS et al. | β | 2015 | β |
| Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children. | Tyrka AR et al. | β | 2015 | β |
| Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling. | Ratajczak T et al. | β | 2015 | β |
| Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. | Sabbagh JJ et al. | β | 2014 | β |
| Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure. | Ewald ER et al. | β | 2014 | β |
| Depletion of FKBP51 in female mice shapes HPA axis activity. | Hoeijmakers L et al. | β | 2014 | β |
| Diverse epigenetic mechanisms of human disease. | Brookes E et al. | β | 2014 | β |
| DNA methylation profiles within the serotonin transporter gene moderate the association of 5-HTTLPR and cortisol stress reactivity. | Alexander N et al. | β | 2014 | β |
| Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. | Wankerl M et al. | β | 2014 | β |
| Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders. | Hing B et al. | β | 2014 | β |
| Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis. | Lee RS et al. | β | 2014 | β |
| Epigenetics, stress, and their potential impact on brain network function: a focus on the schizophrenia diatheses. | Diwadkar VA et al. | β | 2014 | β |
| FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance. | Pereira MJ et al. | β | 2014 | β |
| FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. | HΓΆhne N et al. | β | 2014 | β |
| Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. | Zannas AS et al. | β | 2014 | β |
| Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome. | Fransson L et al. | β | 2014 | β |
| No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision. | Ulirsch JC et al. | β | 2014 | β |
| The future is now: early life events preset adult behaviour. | Patchev AV et al. | β | 2014 | β |
| The neuronal mineralocorticoid receptor: from cell survival to neurogenesis. | Le Menuet D et al. | β | 2014 | β |
| The role of DNA methylation in stress-related psychiatric disorders. | Klengel T et al. | β | 2014 | β |
| Understanding posttraumatic stress disorder: insights from the methylome. | Malan-MΓΌller S et al. | β | 2014 | β |
| Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. | Blair LJ et al. | β | 2013 | β |
| Acute and chronic glucocorticoid treatments regulate astrocyte-enriched mRNAs in multiple brain regions in vivo. | Carter BS et al. | β | 2013 | β |
| Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders? | Klengel T et al. | β | 2013 | β |
| Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. | Klengel T et al. | β | 2013 | β |
| Both transient and continuous corticosterone excess inhibit atherosclerotic plaque formation in APOE*3-leiden.CETP mice. | Auvinen HE et al. | β | 2013 | β |
| Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. | Sinclair D et al. | β | 2013 | β |
| Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. | Yehuda R et al. | β | 2013 | β |
| Epigenetic Risk Factors in PTSD and Depression. | Raabe FJ et al. | β | 2013 | β |
| Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model. | Malviya SA et al. | β | 2013 | β |
| Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder. | Maddox SA et al. | β | 2013 | β |
| Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. | FrΓas-DomΓnguez C et al. | β | 2013 | β |
| Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. | Menke A et al. | β | 2013 | β |
| Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner. | Bourke CH et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. | Daskalakis NP et al. | β | 2013 | β |
| Translational reciprocity: bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain. | Neigh GN et al. | β | 2013 | β |
| Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome. | Polman JA et al. | β | 2013 | β |
| Anatomic, hematologic, and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone. | Cassano AE et al. | β | 2012 | β |
| Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning. | Pascual M et al. | β | 2012 | β |
| Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. | Tyrka AR et al. | β | 2012 | β |
| Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. | Donner NC et al. | β | 2012 | β |
| Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. | Heim C et al. | β | 2012 | β |
| Epigenetic alterations related to early-life stressful events. | Ventura-Junca R et al. | β | 2012 | β |
| Epigenetic changes brought about by perinatal stressors: a brief review of the literature. | Billack B et al. | β | 2012 | β |
| Epigenetic dysregulation of the dopamine system in diet-induced obesity. | Vucetic Z et al. | β | 2012 | β |
| Gene Γ environment vulnerability factors for PTSD: the HPA-axis. | Mehta D et al. | β | 2012 | β |
| Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction. | Guarnieri DJ et al. | β | 2012 | β |
| Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. | Yang X et al. | β | 2012 | β |
| Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders. | Soontornniyomkij V et al. | β | 2012 | β |
| Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. | Galigniana NM et al. | β | 2012 | β |
| Stress and the HPA axis: role of glucocorticoids in alcohol dependence. | Stephens MA et al. | β | 2012 | β |
| Stress-induced sex differences: adaptations mediated by the glucocorticoid receptor. | Bourke CH et al. | β | 2012 | β |
| The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer. | Perisic T et al. | β | 2012 | β |
| The lasting legacy of social stress on the epigenome of the hypothalamic-pituitary-adrenal axis. | Hoffmann A et al. | β | 2012 | β |
| The prospect of FKBP51 as a drug target. | Schmidt MV et al. | β | 2012 | β |
| Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences. | Lee RS et al. | β | 2011 | β |
| A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice. | Lee RS et al. | β | 2011 | β |
| Chronic high-fat diet drives postnatal epigenetic regulation of ΞΌ-opioid receptor in the brain. | Vucetic Z et al. | β | 2011 | β |
| Epigenetics of early child development. | Murgatroyd C et al. | β | 2011 | β |
| Expression and regulation of the Fkbp5 gene in the adult mouse brain. | Scharf SH et al. | β | 2011 | β |
| FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. | Touma C et al. | β | 2011 | β |
| FKBP51 and FKBP52 in signaling and disease. | Storer CL et al. | β | 2011 | β |
| Metabolic syndrome: links to social stress and socioeconomic status. | Tamashiro KL | β | 2011 | β |
| Organization and function of the FKBP52 and FKBP51 genes. | Cioffi DL et al. | β | 2011 | β |
| Reduced expression of MAPK/ERK genes in perinatal arsenic-exposed offspring induced by glucocorticoid receptor deficits. | Martinez-Finley EJ et al. | β | 2011 | β |
| Steroid up-regulation of FKBP51 and its role in hormone signaling. | JÀÀskelΓ€inen T et al. | β | 2011 | β |
| The clinical implications of mouse models of enhanced anxiety. | Sartori SB et al. | β | 2011 | β |
| The growing role of gene methylation on endocrine function. | GarcΓa-Carpizo V et al. | β | 2011 | β |
| Using gene-environment interactions to target personalized treatment in mood disorder. | Klengel T et al. | β | 2011 | β |