major epigenetic marks mediate chromatin state and accessibility of the gene for transcription, their distribution, and reorganization are likely to have significant outcomes. For instance, 5-MeC distinctly relocated from its originally homogeneous distribution in the nucleus, gradually evacuated nucleolus, and finally became confined to the perinucleus (close to nuclear membrane) (Table 2). This transition was concurrent with the progression of the differentiation program of NSCs from the undifferentiated neurosphere, to the differentiating neurosphere core, and finally to the migrated NSCs. The confinement of the inhibitory DNA methylation mark to the perinucleus of more heterochromatin loci would allow for more gene transcription in a greater region of euchromatin in the core of nucleus.
