H. Sample 8) NIMH bipolar vs control: Genome wide association was assessed in controls compared to 461 unrelated bipolar I probands of self-reported European-American ancestry who were selected from families which included at least one affected sibling pair who participated in the NIMH Genetics Initiative (http://nimhgenetics.org) [2]. Probands were assigned a ‘confident’ diagnosis of DSM-IV bipolar I disorder by each of two trained clinicians. 563 unrelated control individuals of European-American ancestry who failed to display evidence for DSM-IV criteria for major depression, any history of bipolar disorder or any history of psychosis were recruited by a marketing firm.
