Chunk #60 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Genotyping for 436,604 autosomal SNPs analyzed was performed using Afymetrix 500k arrays with allele calls made by a CHIAMO algorithm with a ≥ 0.9 a posteriori probability threshold [1]. 436,604 of the 469,557 SNPs assessed could be assigned confident chromosomal localizations. A p value for each SNP was determined based on its χ2 test for significance of allele frequency differences in bipolar vs control (actually control plus other disease) subjects [1].