Chunk #150 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — G. Alzheimer’s disease (Samples 17 and 18)

Source

Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

Embedded

yes

Text

Monte Carlo simulations also document the significant convergence between the results from these two independent studies of Alzheimer’s disease; clustered nominally positive SNPs from both samples identify 99 genes (Uhl et al, submitted). The observed overall convergence between these two datasets was never observed by chance in any of 10,000 simulation trials (thus Monte Carlo p < 0.0001).