Chunk #149 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — G. Alzheimer’s disease (Samples 17 and 18)
There was significant clustering of the SNPs that displayed nominally-positive data in the Alzheimer’s disease genome wide association studies [4, 5]. For Alzheimer’s disease sample 17, 5,428 of 16,224 nominally-positive SNPs identified 1,125 clusters (reanalysis of [4]). For the Alzheimer’s disease sample 18, 7,469 of the 21,600 nominally-positive SNPs fall into 1,436 chromosomal clusters (reanalysis of [5]). We never observed the extents of clustering identified here in any of 100,000 Monte Carlo simulation trials for either sample (p < 0.00001).
