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Chunk #52 — Methods — Comparison between H-MAGMA and cMAGMA

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A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.
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We compared disorder risk genes identified by H-MAGMA with those identified by cMAGMA using a Vennerable package in r. We reported the proportion of H-MAGMA selective genes by calculating the number of genes only identified by H-MAGMA divided by the total number of genes identified by H-MAGMA. Since H-MAGMA results were available from the fetal and adult brain Hi-C data, we used genes that are significantly associated in either fetal or adult dataset using a union function in R (hereby referred to as union disorder risk genes).