We next obtained SNPs mapped to H-MAGMA selective genes using H-MAGMA input files from the fetal and adult brain (H-MAGMA SNPs) and the cMAGMA input file (cMAGMA SNPs). We also obtained H-MAGMA selective SNPs by excluding cMAGMA SNPs from H-MAGMA SNPs to ensure that heritability enrichment we observed is not due to the exonal and promoter SNPs that are shared between H-MAGMA and cMAGMA. We then measured heritability explained by H-MAGMA SNPs and H-MAGMA selective SNPs using stratified linkage disequilibrium score regression with the baseline-LD model (S-LDSC)6.
