Individuals < 22 or > 90 years of age and those with a missing AUD diagnosis were removed from the analyses, leaving 65,387 phase2 EAs (11,337 cases; 54,050 controls). GWAS was then performed on the MVP phase2 dataset. We used logistic regression implemented in PLINK v1.90b4.4 [49] for the AUD GWAS correcting for age, sex, and the first 10 PCs. The mean age is 63.2 (SD=13.4) in the entire MVP sample and 92.5% are males. Data collection and analysis were not performed blind to the conditions of the experiments.
