We used the 46,568 European ancestry subjects (11,569 cases and 34,999 controls) from 27 cohorts that were analyzed by the Psychiatric Genomics Consortium (PGC). The phenotype was lifetime DSM-IV diagnosis of alcohol dependence (AD). The summary data were downloaded from the PGC website (https://www.med.unc.edu/pgc/) with full agreement to the PGC conditions. Allele frequencies were not reported in the summary data. We used allele frequencies from the 1000 Genome European sample as proxy measures in PGC for some downstream analyses.
