The UK Biobank (UKB) included 121,604 White-British unrelated subjects with available AUDIT-P scores. Past-year AUDIT-P was assessed by 7 questions: 1). Frequency of inability to cease drinking; 2). Frequency of failure to fulfil normal expectations due to drinking alcohol; 3). Frequency of needing a morning drink of alcohol after a heavy drinking session; 4). Frequency of feeling guilt or remorse after drinking alcohol; 5). Frequency of memory loss due to drinking alcohol; 6). Been injured or injured someone else through drinking alcohol; 7). Had a relative, friend, or health worker who was concerned about or suggested a reduction in alcohol consumption. The AUDIT-P was log10-transformed for GWAS (see ref [4] for details). We removed SNPs with INFO < 0.7 or call rate < 0.95.
