We performed genome-wide association analyses of three complementary phenotypes: cognitive performance (N = 257,841), self-reported math ability (Math Ability, N = 564,698), and highest math class taken (Highest Math, N = 430,445). For cognitive performance, we meta-analyzed published results from the COGENT Consortium28 with results based on new analyses of the UKB, as did Davies et al.29. For the two math phenotypes, we studied new genome-wide analyses in samples of research participants from 23andMe. We identified 225, 618, and 365 genome-wide significant SNPs for Cognitive Performance, Math Ability, and Highest Math, respectively (Supplementary Figures 14–16, Supplementary Tables 11–13).
