Because the discovery sample used to construct the score consisted of individuals of European ancestry, we would not expect the predictive power of our score to be as high in other ancestry groups7,26,27. Indeed, when our score is used to predict EduYears in a sample of African-Americans from the HRS (N = 1,519), the score only has an incremental R2 of 1.6%, implying an attenuation of 85%. The Supplementary Note shows that this amount of attenuation is typical of what has been reported in previous studies.
