Initially all studies were included in the analysis in order to have a global assessment of disulfiram efficacy, regardless of blind or open-label design. The second step was to test the hypothesis that disulfiram shows no difference compared to the control condition if its administration is blinded. Validating this hypothesis would signify that only open-label designs could indicate a treatment effect. In this case, the following analyses should be conducted only in the open-label condition: supervised versus non supervised administration, cocaine versus non cocaine studies, and disulfiram versus the various control conditions.
