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Chunk #21 — Discussion and conclusions

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Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples.
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The linkage results for Q2 and Q4 (not shown in the figures) did not produce any compelling evidence for the involvement of a well-demarked chromosomal region for these phenotypes. Fisher’s method identified a modest true positive for Q2 on chromosome 8 at PLAT and a modest false positive for Q4 on chromosome 20 at LOC643659. Similarly, the GLMM identified modest true positives for Q2 at SREBF1 on chromosome 17 and at PLAT and a modest false positive for Q4 on chromosome 5 at RNF145.