It would be naïve to expect any single method to pinpoint all the genetic factors that were simulated, especially for private polymorphisms (i.e., polymorphisms found only in a single family or ethnic group). For instance, Hill et al. [9] recently were able to localize a linkage signal for pleuropulmonary blastoma on the basis of a few small families. However, it took a different method (sequencing) to identify the lesions in the responsible gene (DICER1).
