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Chunk #48 — Discussion

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Adolescent but not adult rats exhibit ethanol-mediated appetitive second-order conditioning.
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adult subjects and, as in adolescents, it was exhibited by paired but not control subjects, indicating sensitivity of the wall-climbing measures for adults. The direction of these associations in adults was, however, opposite to that found in adolescents. For adults a negative relationship was observed: the greater the frequency of wall-climbing, the less their preference for CS2. Further research is needed to test the reliability of these apparent associations as well as to scrutinize neural and behavioral mechanisms underlying the expression of ethanol-mediated conditioned preferences and behavioral activation.